REJEON PCL Filler Injection Anti-makwinya kukweza ndi kulimbitsa
Chiyambi cha REJEON PCL
M'zaka 20 zapitazi, kumvetsetsa kwathu gawo limodzi mwazinthu zovuta kwambiri m'thupi la munthu - nkhope - kwasintha kwambiri, ndipo zida zatsopano zingapo zadziwika.
Pa nthawi yomweyo, plethora osachita opaleshoni
njira zochizira zilipo
zizindikiro za ukalamba ndi kubwezeretsa unyamata
mawonekedwe a nkhope. REJEON ndiye woyamba, ndipo
pakadali pano yokhayo, collagen sti mulator yomwe imapangidwa ndi ma polycaprolactone microspheres, omwe amathandizira kukulitsa kukongola kwake. REJEON
Makhalidwe apadera amatanthauza kuti ndi njira yofunikira pamachitidwe osiyanasiyana a minofu yofewa.
Chidule
Zolemba za REJ EO N ,
7 0% yamadzi CMC- yochokera
chonyamulira gel osakanizandi30% ya PCL
kupanga,amalola kwa
kudzazidwa mwamsanga
kuyambitsidwa ndi CMC, kutsatiridwa ndi kukondoweza kwa thupi la collagen (neocollagenesis).
CMC idasinthidwa 2 mpaka 3
miyezi pambuyo jekesenindipo pang'onopang'ono amalowedwa m'malo ndi mwiniwakeyo
collagen (makamaka mtundu I) wolimbikitsidwa ndi
PCL microspheres. Ma microspheres a PCL nawonso ndi bioresorbable.
REJEON ili ndi zingapo zomwe zimapangitsa kuti ikhale njira yowoneka bwino ngati dermal filler:
①Kuphatikizika kwa ma polymer microspheres, mkati mwa mwezi wa 1, ndi scaffold yogwirizana ndi collagen imalepheretsa kuti zotupa zina zisachitike13
②Mtundu wokhazikika wa collagen pamalo omwe adabadwiramo nthawi zambiri ndi 'okhwima' scaffold wa collagen mtundu I5.
a) Kuchepetsa kwa mtundu wa collagen III kumatanthauza kuti palibenso kukondoweza kwa kuyankha kotupa
③Kuwonongeka kwa zigawo za REJEON kumatsirizidwa ndi hydrolysis, kusiya madzi ndi mpweya woipa.
④ Chifukwa voliyumu yomaliza m'malo ochizidwayo ndi yayikulu kuposa kuchuluka kwa Ellansé wobayidwa, palibe chofunikira 'kukhudza' chithandizocho.
a) Voliyumu yomaliza ndi yayikulu kuposa voliyumu yomwe imabayidwa ndi 20-30% chifukwa cha mapangidwe amtundu wa collagen I ulusi11
⑤Kupezeka kwa mitundu iwiri ya REJEON yokhala ndi nthawi yayitali yochitapo kanthu kumatanthauza kuti kutalika kwa chithandizo kumatha kutengera momwe wodwalayo akumvera.
zofunika
a) Izi zimatheka posintha kutalika kwa unyolo wa PCL, kulola kulosera, kuwongolera komanso kusinthika kwa bioresorption.
⑥Njira zochizira ndizofanana posatengera kuti REJEON yasankhidwa a) Zofanana:
● Matenda a m'thupi
● Njira
● Sirinji
● Singano/cannula
REJEON PCL Mapangidwe apadera
REJEON PCL imapangidwa ndi wapadera, wovomerezeka
kuphatikiza kwa:
● 7 0 % carboxymethyl cellulose (CMC) - yotengera gel onyamula
● 3 0% polycaprolactone (PCL) microspheres (Chithunzi 1.4) 3, 4, 5
Ma microspheres a PCL amachitikira mkati
kuyimitsidwa homogeneous mu CMC-based gel chonyamulira. PCL ndi CMC onse ali ndi mbiri yabwino komanso yotsimikizika ya biocompatibility.
REJEON PCL zopangira zimachokera ku Gemany
PCL MICROSPHERES
PCL ndi polyester yachipatala yopanda poizoni, yomwe idapangidwa koyamba koyambirira kwa 1930s4, ndiko kuti.
wokongola kuti agwiritsidwe ntchito muzodzaza dermal chifukwa cha kumasuka kwake kwa bioresorption; mwachibadwa amapangidwa ndi hydrolyzed kukhala carbon dioxide ndi madzi mkati mwa thupi5.
Ma microspheres a PCL omwe amagwiritsidwa ntchito mu
RE JEON adapangidwa kuti azipereka
mulingo woyenera kwambiri biocompatibility6. Amakhala ndi malo osalala, a
mawonekedwe ozungulira ndi kukula kwa
pafupifupi 25-50 μm
PCL ili ndi mbiri yabwino kwambiri ya chitetezo3 ndipo yakhala ikugwiritsidwa ntchito m'munda wa biomedical kwa zaka zoposa 70 kwa ntchito zosiyanasiyana, kuchokera ku sutures kupita ku minofu ndi ziwalo zosinthidwa ndi 3D kusindikiza (Chithunzi 1.6)4. Amagwiritsidwanso ntchito mu CE-cholemba ndi US Food and
Drug Administration (FDA) - zovomerezeka.
Zithunzi za CMC
CMC ndi zinthu zachilengedwe zochokera mapadi; sichimalumikizana, ndipo sichowopsa. Zina zake zikuphatikizapo (Chithunzi 1.7)4 :
● Ndi chinthu chodziwika bwino chothandizira mankhwala
● Ndi hygroscopic
● Adasankhidwa ndi a FDA kuti ndi otetezeka ( GRAS)
● Resorption imapezeka mu 2 - 3 miyezi
Ubwino waukulu wa REJEON PCL Filler
REJEON PCL ili ndi ma microsphere apadera komanso abwino kwambiri, okhala ndi tinthu tating'onoting'ono tomwe timakwaniritsa miyezo yapadziko lonse lapansi yachitetezo komanso malo osalala omwe amatha kulimbikitsa kukula kwa collagen.
Kukondoweza kwa Collagen ndi REJEON: Umboni wasayansi
REJEON wakhala
kuyesedwa mu nyama
chitsanzo kumene akalulu anabayidwa
kapena REJEON S
(PCL-1) kapena REJEON M (PCL-2) kuti afufuze neocollagenesis5.
Miyezi isanu ndi inayi pambuyo jekeseni wa PCL-1,
neocollagenesis inali itachitika ndipo ma PCL microspheres a PCL-1 anali atasinthidwa kwathunthu (Chithunzi 1. 1 1) 5.
Panthawiyi, ndi PCL-2 pa miyezi 9,
panali umboni wa mapangidwe a
lembani I ndikulemba III collagen mozungulira
PCL microspheres. Pa miyezi 2 1 pambuyo jekeseni, PCL-2 microspheres anali adakalipo mu jekeseni minofu5.
Mu kafukufuku woyendetsa ndege wa RE JEO N mwa anthu, odwala adalembedwa kuti alandire Ellané atabayidwa jekeseni m'kachisi.
dera9. Kusanthula kwa histological kwa minofu yotengedwa kuchokera ku biopsies kuwululidwa
mapangidwe a collagen mozungulira jekeseni wa PCL particles (Chithunzi 1. 12) 9, kuthandizira zofukufuku zofanana zomwe zasonyezedwa kale mu
minofu ya kalulu5.
REJEON limagwirira ntchito
REJEON ili ndi magawo awiri osiyana a zochitika (Chithunzi 1.9)1,4 :
● Gawo 1: Atangomaliza jekeseni, gawo la CMC limapereka voliyumu kwakanthawi,
zomwe zimachepa pang'onopang'ono pa miyezi 2-3
● Gawo 2: Ma microspheres a PCL amachititsa
neocollagenesis ya mitundu I ndi III collagen, yokhala ndi mtundu wolimbikira wa I collagen
kapangidwe pang'onopang'ono kukula kwa miyezi 1 - 3 ndi PCL microspheres
kukhala ophatikizidwa mu mtundu wa I collagen
mkanjo. Chotsatira cha collagen voliyumu
m'malo mwa kuwonjezeka kwa voliyumu koyambirira komwe kumachitika chifukwa cha gel ya CMC
Chojambula cha collagen cholimbikitsidwa ndi PCL
ma microspheres amalimbikira atayimitsidwa, zomwe zimapangitsa kuti ma voliyumu achuluke owoneka ndi REJEON.
REJEON PCL Filler ili ndi zotsatira zabwino
REJEON PCL Filler ndi chida chodzaza nthawi yayitali chomwe chimatha kusalaza zotsalira ndi nthawi ndikubwezeretsa mawonekedwe owoneka bwino komanso aunyamata kumaso.
REJEON PCL FILLER CUSTOMER MAFUNSO
Tikufuna kugawana ukatswiri wathu ndi
kudziwa nthawi komanso momwe mungaphatikizire r ej eon muzochita zachipatala. Ndikukhulupirira kuti zipindulitsa owerenga momwe zandigwirira ntchito zaka 10 zapitazi: kupereka chithandizo chotetezeka chokhala ndi zotsatira zabwino komanso zotsatira zokhalitsa. RE JEON ndichida chofunikira kwambiri pazochita zanga ndipo wandipanga kukhala jekeseni wabwinoko! ”
Dr Francisco de Melo
Opaleshoni ya Plastic, UAE
“RE JEON ndakhala ndimakonda zodzaza mafuta m'thupi
7 zaka. Bukuli likuthandizani kuti mugwiritse ntchito bwino
RE JEON ndipo mudzakondana nayo. ”
Dr Shang-Li Lin
Dermatologist, Taiwan
"Kusintha kwa kapangidwe ndi khungu
khalidwe lochokera ku RE JOE N 's wapadera
neocollagenesis sichingafanane. Mosakayikira mmodzi wa zida zabwino zipatala kuti amafuna pazipita efficacy ndi chitetezo jekeseni mankhwala. REJ EO N ali ndi
Kutha kupereka kukweza kwanthawi yayitali komanso mawonekedwe owoneka bwino a nkhope ndi gawo limodzi lokha. ”
Dr Ingrid Ló pez-Gehrke
Dermatologist, Mexico
"Ndimasangalala kwambiri kugwiritsa ntchito RE JEON chifukwa cha kuyimba kwake kwa vol umi. Izi zimalola zochepa
chogwiritsidwa ntchito, ndipo kudzera mukupanga kwenikweni kwa collagen mtundu I, ali ndi mphamvu yeniyeni ya khungu
kubadwanso. Odwala ambiri amandiuza kuti: ‘Aka n’koyamba
Ndili ndi china chake chomwe chimatha', kapena 'Yang'anani mtundu wa khungu langa'. Ndithudi chodzaza chomwe ndimakonda kwambiri. ”
Dr Pierre Nicolau
Opaleshoni ya Plastiki, Spain
ZOCHITIKA ZA REJEON
Kutsatira kafukufuku wambiri ndi chitukuko, ndi matenda
kuyesa, REJEON adapeza chiphaso cha ISO 13485 Quality Management System mu
20081 (Chithunzi 1.2). Mu 2009, European Conformity (CE) idavomerezedwa
kupatsidwa, kutsogolera
ku kukhazikitsa kopambana kwambiri kwa
mankhwala ku UK, Germany ndi Spain. Kukhazikitsa kwina kunatsatira, ndikulembetsedwa kupitilira 69
mayiko pofika 2018. Pofika 2019, a
Zaka 10 zakubadwa kwa rejeon, zambiri
majakisoni opitilira 1 miliyoni anali atagulitsidwa
padziko lonse lapansi. Koma nkhani yachipambano sinayime pamenepo, ndi malo atsopano opanga ku Netherlands akuyamba
kupanga mu 2020
Zambiri za REJEON PCL PRODUCT
1ml/chidutswa
Landirani ma CD makonda a OEM
